Michael Joiner
Narrative Bio
Education:
(1980) Ph.D. Institute of Cancer Research (Royal Postgraduate Medical School), University of London, London, UK
(1980) M.A. Queens' College, University of Cambridge, Cambridge, UK
(1976) B.A. Queens' College, University of Cambridge, Cambridge, UK
Post Graduate Training
(1980) Research Scientist, CRC Gray Laboratory, Mount Vernon Hospital, Northwood, Middlesex, UK
Faculty Appointments
(2002-Present) Professor (Tenured), Department of Oncology, Division of Radiation Oncology, Wayne State University School of Medicine, Detroit, MI USA
(1997-2002) Research Scientist, Special appointment grade, CRC Gray Laboratory, Mount Vernon Hospital, Northwood, Middlesex, UK
(1988-1997) Research Scientist, Tenured appointment, senior grade, CRC Gray Laboratory, Mount Vernon Hospital, Northwood, Middlesex, UK
Hospital or Other Professional Appointments
(2015-Present) Member, Departmental Promotions and Tenure Committee, Department of Oncology, Wayne State University, Detroit, MI
(2012-Present) Member, Committee of the Associate Chairs for Research, Wayne State University School of Medicine, Detroit, MI
(2012-Present) Member, AAPM Working Group on Stereotactic Body Radiotherapy
(2011-Present) Member, Committee on Bioeffect Modeling and Biologically Equivalent Dose Concepts in Radiation Therapy of the International Commission on Radiation Units and Measurement (ICRU)
(2011-Present) Member, Radiobiology Practice Exam and Study Guide Subcommittee of the ASTRO Radiation and Cancer Biology Committee
(2008-Present) Member, Radiation Safety Committee, Division of Radiation Oncology, Department of Oncology, Wayne State University, Detroit, MI
(2005-Present) Member, Graduate Committee, Wayne State University School of Medicine Medical Physics Graduate Program, Detroit, MI
(2005-Present) Member, Curriculum & Evaluations Committee, Wayne State University School of Medicine Medical Physics Graduate Program, Detroit, MI
(2005-Present) Member, Admissions Committee, Wayne State University School of Medicine Medical Physics Graduate Program, Detroit, MI
(2001-Present) Head of Radiation Biology Program, Department of Oncology, Division of Radiation Oncology, Wayne State University, Detroit, MI
(2000) Honorary Professor, Department of Oncology, University College, London, UK
(1996) Honorary Professor Associate, Brunel University, Uxbridge, Middlesex, UK
(1989) Head of Experimental Oncology, Gray Laboratory Cancer Research Trust, Mount Vernon Hospital, Northwood, Middlesex, UK
Major Professional Societies
AACR: American Association for Cancer Research
ASTRO: American Society for Radiation Oncology
RRS: Radiation Research Society
RSNA: Radiological Society of North America
ESTRO: European Society for Radiotherapy and Oncology
ARR: Association for Radiation Research
University of London Convocation
Areas of Interest
Molecular basis for clinical radiation resistance and diversity seen in the response to radiation therapy, including the study of cancer stem cells;
Development of a complete system of treatment planning based on biologically effective dose to improve our ability to account for variability in biological factors such as radiosensitivity, hypoxia and cell proliferation from patient to patient;
Investigation of soy isoflavones to enhance radiotherapy;
Gene therapy and therapeutic use of stem cells for radioprotection of normal tissues;
Development of high-LET radiotherapy;
Nanoparticles to enhance the radiation effect on radioresistant tumors.
Publications
- Joiner MC, Denekamp J, Maughan RL. The use of ‘top-up’ experiments to investigate the effect of very small doses per fraction in mouse skin. Int J Radiat Biol 1986;49:565-80.
- Marples B, Joiner MC. The response of Chinese hamster V79 cells to low radiation doses: evidence of enhanced sensitivity of the whole cell population. Radiat Res 1993;133:41-51.
- Joiner MC, Mogili N, Marples B, Burmeister J. Significant dose can be lost by extended delivery times in IMRT with x rays but not high-LET radiations. Med Phys 2010;37:2457-65.
- Hillman GG, Singh-Gupta V, Hoogstra DJ, Abernathy L, Rakowski J, Yunker CK, Rothstein SE, Sarkar FH, Gadgeel S, Konski AA, Lonardo F, Joiner MC. Differential effect of soy isoflavones in enhancing high intensity radiotherapy and protecting lung tissue in a pre-clinical model of lung carcinoma. Radiother Oncol 2013;109:117-25.
- Seth I, Joiner MC, Tucker JD. Cytogenetic low-dose hyper-radiosensitivity is observed in human peripheral blood lymphocytes. Int J Radiat Oncol Biol Phys 2015;91:82-90.
Position Title
Professor - Department of Oncology (Radiation Oncology)Director, Radiation Biology Program