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Michael Joiner, Ph.D.
Biography
Education:
Baccalaureate:
Queens' College, University of Cambridge, Cambridge, UK
BA (1976)
MA (1980)
Graduate:
Institute of Cancer Research (Royal Postgraduate Medical School), University of London, London, UK
PhD (1980)
Training:
January 1980
Research Scientist
CRC Gray Laboratory, Mount Vernon Hospital, Northwood, Middlesex, UK
Faculty Appointments:
April 1988 - April 1997
Research Scientist, Tenured appointment, senior grade, CRC Gray Laboratory, Mount Vernon Hospital, Northwood, Middlesex, UK
April 1997 - February 2002
Research Scientist, Special appointment grade, CRC Gray Laboratory, Mount Vernon Hospital, Northwood, Middlesex, UK
February 2002 - present
Professor (tenured), Department of Radiation Oncology, Wayne State University School of Medicine, Detroit, MI USA
Hospital / Professional Appointments:
January 1989
Head of Experimental Oncology, Gray Laboratory Cancer Research Trust, Mount Vernon Hospital, Northwood, Middlesex, UK
December 1996
Honorary Professor Associate, Brunel University, Uxbridge, Middlesex, UK
November 2000
Honorary Professor, Department of Oncology, University College, London, UK
October 2001 - present
Head of Radiation Biology Program, Department of Radiation Oncology, Karmanos Cancer Institute, Detroit, MI, USA
Publications
Original observations in refereed journals:
1. Joiner M.C. The effect on experimental tumours of hyperthermia in combination with cytotoxic drugs or gamma radiation with special reference to ultrasound as a method of heating. Ph.D. Thesis, University of London, 1980.
2. Denekamp J., McNally N.J., Fowler J.F. and Joiner M.C. Misonidazole in fractionated radiotherapy: are many small fractions best? British Journal of Radiology, 53, 981-990, 1980.
3. Peacock J.H., Joiner M.C. and Stephens T.C. Modification of tumour cell kill by anaesthetics. British Journal of Cancer, 41, Suppl. IV, 311, 1980.
4. Joiner M.C., Steel G.G. and Stephens T.C. Response of two mouse tumours to hyperthermia with CCNU or melphalan. British Journal of Cancer, 45, 17-26, 1982.
5. Joiner M.C. and Vojnovic B. Radiofrequency diathermy for uniform heating of mouse tumours. British Journal of Cancer, 45 Suppl. V, 71-76, 1982.
6. Denekamp J. and Joiner M.C. The potential benefit from a perfect radiosensitizer and its dependence on reoxygenation. British Journal of Radiology, 55, 657-663, 1982.
7. Joiner M.C., Maughan R.L., Fowler J.F. and Denekamp J. The RBE for mouse skin irradiated with 3-MeV neutrons: single and fractionated doses. Radiation Research, 95, 130-141, 1983.
8. Joiner M.C., Bremner J.C. and Denekamp J. The therapeutic advantage of combined X-rays and melphalan. International Journal of Radiation Oncology Biology Physics, 10, 385-392, 1984.
9. Denekamp J., Joiner M.C. and Maughan R.L. Neutron RBEs for mouse skin at low doses per fraction. Radiation Research, 98, 317-331, 1984.
10. Joiner M.C., Bremner J.C., Denekamp J. and Maughan R.L. The interaction between X-rays and 3 MeV neutrons in the skin of the mouse foot. International Journal of Radiation Biology, 46, 625-638, 1984.
11. Joiner M.C., Hill S.A., Bremner J.C., Smith K.A. and Denekamp J. The influence of pre-treatment temperature on the thermal sensitivity of a mouse tumour. International Journal of Radiation Biology, 48, 235-250, 1985.
12. Vojnovic B. and Joiner M.C. A multiple RF heating system for experimental hyperthermia in small animals. International Journal of Hyperthermia, 1, 287-298, 1985.
13. Joiner M.C. and Michael B.D. A cautionary note on the use of ionization chambers for radiation dosimetry in different gas mixtures. International Journal of Radiation Biology, 49, 163-164, 1986.
14. Joiner M.C. and Denekamp J. Evidence for a constant repair capacity over 20 fractions of X-rays. International Journal of Radiation Biology, 49, 143-150, 1986.
15. Joiner M.C., Denekamp J. and Maughan R.L. The use of ‘top-up’ experiments to investigate the effect of very small doses per fraction in mouse skin. International Journal of Radiation Biology, 49, 565-580, 1986.
16. Joiner M.C. and Denekamp J. The effect of small radiation doses on mouse skin. British Journal of Cancer, 53 Suppl. VII, 63-66, 1986.
17. Joiner M.C. Extension of the reciprocal dose analysis to the case of multiple fractions plus top-up. Radiotherapy and Oncology, 7, 349-351, 1986.
18. Carl U.M., McNally N.J. and Joiner M.C. The effect of mixed fractionation with X rays and neutrons on tumour growth delay and skin reactions in mice. British Journal of Radiology, 60, 583-588, 1987.
19. Joiner M.C. The design and interpretation of ‘top-up’ experiments to investigate the effects of low radiation doses. International Journal of Radiation Biology, 51, 115-130, 1987.
20. Joiner M.C. and Johns H. Renal damage in the mouse: the effect of d(4)-Be neutrons. Radiation Research, 109, 456-468, 1987.
21. Joiner M.C. and Johns H. Renal damage in the mouse: The response to very small doses per fraction. Radiation Research, 114, 385-398, 1988.
22. Joiner M.C. and Field S.B. The response of mouse skin to irradiation with neutrons from the 62 MV cyclotron at Clatterbridge, U.K. Radiotherapy and Oncology, 12, 153-166, 1988.
23. Joiner M.C. A comparison of the effects of p(62)-Be and d(16)-Be neutrons in the mouse kidney. Radiotherapy and Oncology, 13, 211-224, 1988.
24. Rojas A. and Joiner M.C. The influence of dose per fraction on repair kinetics. Radiotherapy and Oncology, 14, 329-336, 1989.
25. Stevens G.N., Joiner M.C., Joiner B., Johns H. and Stratford M.R. Role of glutathione peroxidase in the radiation response of mouse kidney. International Journal of Radiation Oncology Biology Physics, 16, 1213-1217, 1989.
26. Joiner M.C., Rojas A. and Johns H. Does the repair capacity of skin change with repeated exposure to X-rays? International Journal of Radiation Biology, 55, 993-1005, 1989.
27. Fowler J.F., Whitsed C.A. and Joiner M.C. Repair kinetics in mouse lung: a fast component at 1.1 Gy per fraction. International Journal of Radiation Biology, 56, 335-353, 1989.
28. Rojas A., Joiner M.C. and Johns H. Recovery kinetics in mouse skin and CaNT tumours. Radiotherapy and Oncology, 16, 211-220, 1989.
29. Nilsson P., Thames H.D. and Joiner M.C. A generalized formulation of the ‘incomplete-repair’ model for cell survival and tissue response to fractionated low dose-rate irradiation. International Journal of Radiation Biology, 57, 127-142, 1990.
30. Joiner M.C., Rojas A. and Michael B.D. The influence of experimental design and data analysis on the determination of recovery kinetics of radiation damage between acute dose-rate treatments in vivo. International Journal of Radiation Biology, 57, 143-162, 1990.
31. Field S.B. and Joiner M.C. Expression of dose in neutron therapy. Radiotherapy and Oncology, 17, 73-80, 1990.
32. Tsang R.W., Joiner M.C., Rojas A. and Johns H. Repopulation in murine skin after X-ray treatments with multiple fractions per day. Radiation Research, 125, 163-172, 1991.
33. Rojas A., Joiner M.C. and Johns H. Recovery kinetics of X-ray damage in mouse skin: the influence of dose per fraction. International Journal of Radiation Biology, 59, 517-536, 1991.
34. Stevens G., Joiner M., Joiner B., Johns H. and Denekamp J. Early detection of damage following bilateral renal irradiation in the mouse. Radiotherapy and Oncology, 20, 124-131, 1991.
35. Johns H. and Joiner M.C. A simple method for fitting curves to dose-effect data for functional damage. International Journal of Radiation Biology, 60, 533-541, 1991.
36. Kjellen E., Joiner M.C., Collier J.M., Johns H. and Rojas A. A therapeutic benefit from combining normobaric carbogen or oxygen with nicotinamide in fractionated X-ray treatments. Radiotherapy and Oncology, 22, 81-91, 1991.
37. Joiner M.C., Rojas A. and Johns H. A test of equal effect per fraction in the kidney of the mouse. Radiation Research, 130, 227-235, 1992.
38. Rojas A., Joiner M.C., Hodgkiss R.J., Carl U., Kjellen E. and Wilson G.D. Enhancement of tumor radiosensitivity and reduced hypoxia-dependent binding of a 2-nitroimidazole with normobaric oxygen and carbogen: a therapeutic comparison with skin and kidneys. International Journal of Radiation Oncology Biology Physics, 23, 361-366, 1992.
39. Stratford M.R., Rojas A., Hall D.W., Dennis M.F., Dische S., Joiner M.C. and Hodgkiss R.J. Pharmacokinetics of nicotinamide and its effect on blood pressure, pulse and body temperature in normal human volunteers. Radiotherapy and Oncology, 25, 37-42, 1992.
40. Marples B. and Joiner M.C. The response of Chinese hamster V79 cells to low radiation doses: evidence of enhanced sensitivity of the whole cell population. Radiation Research, 133, 41-51, 1993.
41. Lambin P., Marples B., Malaise E.P., Fertil B. and Joiner M.C. Hypersensitivity of a human tumour cell line to very low radiation doses. International Journal of Radiation Biology, 63, 639-650, 1993.
42. Joiner M.C., Rojas A. and Johns H. Renal damage in the mouse: Repair kinetics at 2 and 7 Gy per fraction. Radiation Research, 134, 355-363, 1993.
43. Lambin P., Malaise E.P. and Joiner M.C. Megafractionnement: une methode pour agir sur les tumeurs intrinsequement radioresistantes? Bulletin du Cancer (Radiotherapie), 80, 417-423, 1993.
44. Lambin P., Coco-Martin J., Legal J.D., Begg A.C., Parmentier C., Joiner M.C. and Malaise E.P. Intrinsic radiosensitivity and chromosome aberration analysis using fluorescence in situ hybridization in two human tumor cell lines. Radiation Research, 138, S40-S43, 1994.
45. Lambin P., Fertil B., Malaise E.P. and Joiner M.C. Multiphasic survival curves of human tumour cell lines: induced repair or hypersensitive subpopulation? Radiation Research, 138, S32-S36, 1994.
46. Lambin P., Malaise E.P. and Joiner M.C. The effect of very low radiation doses on the human bladder carcinoma cell line RT112. Radiotherapy and Oncology, 32, 63-72, 1994.
47. Lawton P.A., Hodgkiss R.J., Eyden B.P. and Joiner M.C. Growth of fibroblasts as a potential confounding factor in soft agar clonogenic assays for tumour cell radiosensitivity. Radiotherapy and Oncology, 32, 218-225, 1994.
48. Malaise E.P., Lambin P. and Joiner M.C. Radiosensitivity of human cell lines to small doses. Are there some clinical implications? Radiation Research, 138, S25-S27, 1994.
49. Marples B., Joiner M.C. and Skov K.A. The effect of oxygen on low dose hypersensitivity and increased radioresistance in V79-379A cells. Radiation Research, 138, S17-S20, 1994.
50. Singh B., Arrand J.E. and Joiner M.C. Hypersensitive response of normal human lung epithelial cells at low radiation doses. International Journal of Radiation Biology, 65, 457-464, 1994.
51. Skov K., Marples B., Matthews J.B., Joiner M. and Zhou H. A preliminary investigation into the extent of increased radioresistance (IRR) or hyper-radiosensitivity (HRS) in hamster cell lines known to be deficient in DNA repair. Radiation Research, 138, S126-S129, 1994.
52. Stevens G.N., Hill S.A., Joiner M.C., Joiner B., Johns H., Williams K.B., Denekamp J. and Nethersell A.B. The effect of BW12C on the radiosensitivity and necrosis of murine tissues and tumours. Australasian Radiology, 38, 199-203, 1994.
53. Johns H., Morris W.J. and Joiner M.C. Radiation response of murine eccrine sweat glands. Radiotherapy and Oncology, 36, 56-64, 1995.
54. Judas L., Bentzen S.M., Johns H., Joiner M.C. and Morris W.J. Time evolution of the number of functional murine eccrine sweat glands after irradiation: a quantitative analysis of experimental data using a model of proliferative and functional organization. International Journal of Radiation Biology, 67, 565-575, 1995.
55. Marples B. and Joiner M.C. The elimination of low-dose hypersensitivity in V79-379A cells by pre-treatment with x-rays or hydrogen peroxide. Radiation Research, 141, 160-169, 1995.
56. Stevens G., Joiner M., Joiner B., Johns H. and Denekamp J. Radiosensitization of mouse skin by oxygen and depletion of glutathione. International Journal of Radiation Oncology Biology Physics, 33, 399-408, 1995.
57. Joiner M.C., Lambin P., Malaise E.P., Robson T., Arrand J.E., Skov K. and Marples B. Hypersensitivity to very-low single radiation doses: Its relationship to the adaptive response and induced radioresistance. Mutation Research, 358, 171-183, 1996.
58. Lambin P., Malaise E.P. and Joiner M.C. Might intrinsic radioresistance of human tumour cells be induced by radiation? International Journal of Radiation Biology, 69, 279-290, 1996.
59. Rojas A., Denekamp J., Johns H., Kjellen E., Tsang R., Nilsson P., Stratford M.R.L., Dennis M.F. and Joiner M.C. Nicotinamide as a repair inhibitor in vivo: Studies using single and fractionated X-ray doses in mouse skin and kidneys. Radiation Research, 145, 419-431, 1996.
60. Rojas A., Vojnovic B., Johns H., Joiner M.C., Martindale C., Fowler J.F. and Denekamp J. Radiosensitisation in normal tissues with oxygen, carbogen and nicotinamide: therapeutic gain comparisons for fractionated X-ray schedules. Radiotherapy and Oncology, 39, 53-64, 1996.
61. Robson T., Lohrer H., Bailie J.R., Hirst D.G., Joiner M.C. and Arrand J.E. Gene regulation by low dose ionizing radiation in a normal human lung epithelial cell line. Biochemical Society Transactions, 25, 335-342, 1997.
62. Marples B. Lambin P., Skov K.A. and Joiner M.C. Low dose hyper-radiosensitivity (HRS) and increased radioresistance (IRR) in mammalian cells. International Journal of Radiation Biology, 71, 721-735, 1997.
63. Hasan N.M., Adams G.E., Joiner M.C., Marshall J.F. and Hart I.R. Hypoxia facilitates tumour cell detachment by reducing expression of surface adhesion molecules and adhesion to extracellular matrices without loss of cell viability. British Journal of Cancer, 77, 1799-1805, 1998.
64. Hasan N.M., Adams G.E. and Joiner M.C. Effect of serum starvation on expression and phosphorylation of PKC-alpha and p53 in V79 cells: Implications for cell death. International Journal of Cancer, 80, 400-405, 1999.
65. Cummins R.J., Mothersill C., Seymour C.B., Johns H. and Joiner M.C. The effect of microcolony size at time of irradiation on colony forming ability. International Journal of Radiation Biology, 75, 225-232, 1999.
66. Short S.C., Mayes C., Woodcock M., Johns H. and Joiner M.C. Low dose hypersensitivity in the T98G human glioblastoma cell line. International Journal of Radiation Biology, 75, 847-855, 1999.
67. Robson T., Joiner M.C., Wilson G.D., McCullough W., Price M.E., Logan I., Jones H., McKeown S.R. and Hirst D.G. A novel human stress response-related gene with a potential role in induced radioresistance. Radiation Research, 152, 451-461, 1999.
68. Short S.C., Mitchell S.A., Boulton P., Woodcock M. and Joiner M.C. The response of human glioma cell lines to low-dose radiation exposure. International Journal of Radiation Biology, 75, 1341-1348, 1999.
69. Marples B. and Joiner M.C. Modification of survival by DNA repair modifiers: a probable explanation for the phenomenon of increased radioresistance. International Journal of Radiation Biology, 76, 305-312, 2000.
70. Robson T., Price M.E., Moore M.L., Joiner M.C., McKelvey-Martin V.J., McKeown S.R. and Hirst D.G. Increased repair and cell survival in cells treated with DIR1 antisense oligonucleotides: implications for induced radioresistance. International Journal of Radiation Biology, 76, 617-623, 2000.
71. Gamble S.C., Dunn M.J., Wheeler C.H., Joiner M.C., Adu-Poku A. and Arrand J.E. Expression of proteins coincident with inducible radioprotection in human lung epithelial cells. Cancer Research, 60, 2146-2151, 2000.
72. Vaganay-Juéry S., Muller C., Abdulkarim B., Deutsch E., Marangoni E., Lambin P., Calsou P., Salles B., Joiner M. and Bourhis J. Decreased DNA-PK activity in human cancer cells exhibiting hypersensitivity to low-dose irradiation. British Journal of Cancer, 83, 514-518, 2000.
73. Moussa H., Mitchell S.A., Grénman R. and Joiner M.C. Cell-cell contact increases radioresistance in head and neck carcinoma cell lines. International Journal of Radiation Biology, 76, 1245-1253, 2000.
74. Barber P.R., Vojnovic B., Kelly J., Boulton P., Mayes C., Woodcock M. and Joiner M.C. Automated counting of mammalian cell colonies. Physics in Medicine and Biology, 46, 63-76, 2001.
75. Aird E.G., Folkard M., Mayes C.R., Bownes P.J., Lawson J.M. and Joiner M.C. A purpose built Iodine-125 irradiation plaque for low-dose rate low energy irradiation of cell lines in-vitro. British Journal of Radiology, 74, 56-61, 2001.
76. Short S.C., Kelly J., Mayes C.R., Woodcock M. and Joiner M.C. Low-dose hypersensitivity after fractionated low-dose irradiation in vitro. International Journal of Radiation Biology, 77, 655-664, 2001.
77. Mothersill C., Seymour C.B. and Joiner M.C. Relationship between low dose hyper-radiosensitivity (HRS) and the “bystander effect”. Radiation Research, 157, 526-532, 2002.
78. Mitchell C.R., Folkard M. and Joiner M.C. Effects of low dose-rate 60Co gamma-ray exposure on human tumor cells in vitro. Radiation Research, 158, 311-318, 2002.
79. Scott S.D., Joiner M.C. and Marples B. Optimizing radiation-responsive gene promoters for radiogenetic cancer therapy. Gene Therapy, 9, 1396-1402, 2002.
80. Mitchell C.R. and Joiner M.C. The effect of subsequent acute-dose irradiation on cell survival in vitro following low dose-rate exposures. International Journal of Radiation Biology, 78, 981-990, 2002.
81. Marples B., Cann N.E., Mitchell C.R., Johnston P.J. and Joiner M.C. Evidence for the involvement of DNA-dependent protein kinase in the phenomena of low dose hyper-radiosensitivity and increased radioresistance. International Journal of Radiation Biology, 78, 1139-1147, 2002.
82. Short S.C., Woodcock M., Marples B. and Joiner M.C. Effects of cell cycle phase on low-dose hyper-radiosensitivity. International Journal of Radiation Biology, 79, 99-105, 2003.
83. Marples B., Wouters B.G. and Joiner M.C. An association between the radiation-induced arrest of G2 cells and low-dose hyper-radiosensitivity: A plausible underlying mechanism? Radiation Research, 160, 38-45, 2003.
84. Krause M., Hessel F., Wohlfarth J., Zips D., Hoinkis C., Foest H., Petersen C., Short S.C., Joiner M.C. and Baumann M. Ultrafractionation in A7 human malignant glioma in nude mice. International Journal of Radiation Biology, 79, 377-383, 2003.
85. Marples B., Greco O., Joiner M.C., Scott S.D. Radiogenetic therapy: strategies to overcome tumor resistance. Current Pharmaceutical Design, 9, 2105-2112, 2003.
86. Greco O., Marples B., Joiner M.C. and Scott S.D. How to overcome (and exploit) tumor hypoxia for targeted gene therapy. Journal of Cellular Physiology, 197, 312-325, 2003.
87. Chalmers A., Johnston P., Woodcock M., Joiner M. and Marples B. PARP-1, PARP-2, and the cellular response to low doses of ionizing radiation. International Journal of Radiation Oncology Biology Physics, 58, 410-419, 2004.
88. Joiner M.C. A simple a/b-independent method to derive fully isoeffective schedules following changes in dose per fraction. International Journal of Radiation Oncology Biology Physics, 58, 871-875, 2004.
89. Harney J., Shah N., Short S., Daley F., Groom N., Wilson G.D., Joiner M.C. and Saunders M.I. The evaluation of low dose hyper-radiosensitivity in normal human skin. Radiotherapy and Oncology, 70, 319-329, 2004.
90. Harney J., Short S., Shah N., Joiner M.C. and Saunders M.I. Low dose hyper-radiosensitivity in metastatic tumors. International Journal of Radiation Oncology Biology Physics, 59, 1190-1195, 2004.
91. Hillman G.G., Wang Y., Kucuk O., Che M., Doerge D.R., Wright J.L., Yudelev M., Joiner M.C., Marples B., Forman J.D. and Sarkar F.H. Genistein potentiates inhibition of tumor growth by radiation in a prostate cancer orthotopic model. Molecular Cancer Therapeutics, 3, 1271-1279, 2004.
92. Greco O., Joiner M.C., Doleh A. and Scott S.D. VP22-mediated intercellular transport for suicide gene therapy under oxic and hypoxic conditions. Gene Therapy, 12, 974-979, 2005.
93. Greco O., Powell T.M., Marples B., Joiner M.C. and Scott S.D. Gene therapy vectors containing CArG elements from the Egr1 gene are activated by neutron irradiation, cisplatin and doxorubicin. Cancer Gene Therapy, 12, 655-662, 2005
94. Krause M., Prager J., Wohlfarth J., Hessel F., Haase M., Joiner M.C. and Baumann M. Ultrafractionation does not improve the results of radiotherapy in radioresistant murine DDL1 lymphoma. Strahlentherapie und Onkologie, 181, 540-544, 2005.
95. Krause M., Wohlfarth J., Georgi B., Pimentel N., Dorner D., Zips D., Eicheler W., Hessel F., Short S.C., Joiner M.C. and Baumann M. Low-dose hyperradiosensitivity of human glioblastoma cell lines in vitro does not translate into improved outcome of ultrafractionated radiotherapy in vivo. International Journal of Radiation Biology, 81, 751-758, 2005.
96. Greco O., Joiner M.C., Doleh A., Powell A.D., Hillman G.G. and Scott S.D. Hypoxia- and radiation-activated Cre/loxP \'molecular switch\' vectors for gene therapy of cancer. Gene Therapy, 181, 206-215, 2006.
97. Wykes S.M., Piasentin E., Joiner M.C., Wilson G.D. and Marples B. Low-dose hyper-radiosensitivity is not a failure to recognize DNA double-strand breaks. Radiation Research, 165, 516-524, 2006.
98. Wang Y., Raffoula J.J., Che M., Doergee D.R., Joiner M.C., Kucuk O., Sarkar F.H. and Hillman G.G. Prostate cancer radiotherapy is enhanced by genistein in vitro and in vivo using a syngeneic orthotopic tumor model. Radiation Research, 166, 73-80, 2006.
99. Krueger S.A., Joiner M.C., Weinfeld M., Piasentin E. and Marples B. Role of apoptosis in low-dose hyper-radiosensitivity. Radiation Research, 167, 260-267, 2007.
100. Sgouros G., Knox S.J., Joiner M.C., Morgan W.F. and Kassis A.I. MIRD Continuing education: Bystander and low dose rate effects - are these relevant to radionuclide therapy? Journal of Nuclear Medicine, 48, 1683-1691, 2007.
101. Krueger S.A., Collis S.J., Joiner M.C., Wilson G.D. and Marples B. Transition in survival from low-dose hyper-radiosensitivity to increased radioresistance is independent of activation of ATM Ser1981 activity. International Journal of Radiation Oncology Biology Physics, 69, 1262-1271, 2007.
In Press
Submitted (dates expected)
102. Powell A.D., Che M., Forman J.D., Joiner M.C., Marples B. and Wilson G.D. Hypoxia-regulated protein expression in prostate cancer. Radiation Research, 2008.
103. Ryan L.A., Seymour C.B., Joiner M.C. and Mothersill C.E. Radiation-induced adaptive response segregates with low-dose hypersensitivity/increased radioresistance, not the bystander effect. Radiation Research, 2008.
Review Articles
104. Carnochan P., Dickinson R.J. and Joiner M.C. The practical use of thermocouples for temperature measurement in clinical hyperthermia. International Journal of Hyperthermia, 2, 1-19, 1986.
105. Joiner M.C. Induced radioresistance: an overview and historical perspective. International Journal of Radiation Biology, 65, 79-84, 1994.
106. Joiner M.C. Evidence for induced resistance from survival and other endpoints: an introduction. Radiation Research, 138, S5-S8, 1994.
107. Turesson I. and Joiner M.C. Clinical evidence of hypersensitivity to low doses in radiotherapy. Radiotherapy and Oncology, 40, 1-3, 1996.
108. Adams G.E., Hasan N.M. and Joiner M.C. Radiation, hypoxia and genetic stimulation: implications for future therapies. Radiotherapy and Oncology, 44, 101-109, 1997.
109. Short S.C. and Joiner M.C. Cellular response to low-dose irradiation. Clinical Oncology, 10, 73-77, 1998.
110. Joiner M.C., Lambin P. and Marples B. Adaptive response and induced resistance. Comptes Rendus de l\'Académie des Sciences Série III, 322, 167-175, 1999.
111. Marples B., Greco O., Joiner M.C. and Scott S.D. Molecular approaches to chemo-radiotherapy. European Journal of Cancer, 38, 231-239, 2002.
112. Marples B., Wouters B.G., Collis S.J., Chalmers A.J. and Joiner M.C. Low-dose hyper-radiosensitivity: a consequence of ineffective cell cycle arrest of radiation-damaged G2-phase cells. Radiation Research, 161, 247-255, 2004.
113. Joiner M.C. New frontiers or red herrings in radiation oncology research? Lancet Oncology, 5, 10, 2004.
114. Joiner M.C. Introduction: Basic radiation research into the new millennium. Cancer and Metastasis Reviews, 23, 193-195, 2004.
115. Greco O., Marples B., Wilson G.D., Joiner M.C. and Scott S.D. Radiation-induced gene therapy. Radiation Research, 163, 707-708, 2005.
116. White J. and Joiner M.C. Toxicity from radiation in breast cancer. Cancer Treatment and Research, 128, 65-109, 2005.
Books, Chapters, Proceedings and Letters
117. Joiner M.C. Enhancement of cell killing by combination of drugs and hyperthermia in two mouse tumours. In: Proc. 1st Meeting of European Group of Hyperthermia in Radiation Oncology. Edited by: G. Arcangeli and F. Mauro. (Masson-Italia, Milan), pp. 157-164, 1980.
118. Fowler J.F., Joiner M.C. and Williams M.V. Low doses per fraction in radiotherapy: a definition for “flexure dose” [letter]. British Journal of Radiology, 56, 599-601, 1983.
119. Carl U.M., McNally N.J. and Joiner M.C. Change in therapeutic gain with photon contamination in a neutron beam [letter]. British Journal of Radiology, 60, 937-938, 1987.
120. Joiner M.C. The dependence of radiation response on the dose per fraction. In: The Scientific Basis for Modern Radiotherapy (BIR Report 19). Edited by: N.J. McNally. (British Institute of Radiology, London), pp. 20-26, 1989.
121. Field S.B. and Joiner M.C. Reply to letter by A. Wambersie and B.J. Mijnheer. Radiotherapy and Oncology, 17, 263-264, 1990.
122. Joiner M.C. and McNally N.J. Experimental studies with mixed-LET beams at the Gray Laboratory. Nuclear Science Applications, 4, 81-94, 1991.
123. Joiner M.C. Summary of the platform and poster presentations on radiobiology. Nuclear Science Applications, 4, 475-477, 1991.
124. Rojas A., Joiner M.C. and Denekamp J. Extrapolations from laboratory and preclinical studies for the use of carbogen and nicotinamide in radiotherapy [letter]. Radiotherapy and Oncology, 24, 123-124, 1992.
125. Marples B., Joiner M.C. and Skov K.A. An X-ray inducible repair response: evidence from high resolution survival measurements in air and hypoxia. In: Low dose irradiation and biological defense mechanisms. Edited by: T. Sugahara, L.A. Sagan and T. Aoyama. (Elsevier, Amsterdam), pp. 295-298, 1992.
126. Joiner M.C. and Marples B. Does induced repair determine the lethal effects of very low radiation doses? In: Radiation Science: Of Molecules, Mice and Men (BJR Supplement 24). Edited by: J. Denekamp and D.G. Hirst. (British Institute of Radiology, London), pp. 74-78, 1992.
127. Rojas A., Denekamp J. and Joiner M.C. ARCON: accelerated radiotherapy with carbogen and nicotinamide. In: Bioreductive drugs, sensitizers, oxygen and radiotherapy. Edited by: W. Dobrowsky. (Facultas-Universitatsverlag, Vienna), pp. 101-114, 1993.
128. Joiner M.C., Marples B. and Johns H. The response of tissues to very low doses per fraction: A reflection of induced repair? In: Acute and Long-Term Side-Effects of Radiotherapy. Biological Basis and Clinical Relevance. Edited by: W. Hinkelbein, G. Bruggmoser, H. Frommhold and M. Wannenmacher. (Springer-Verlag, Berlin), Recent Results in Cancer Research, 130, 27-40, 1993.
129. Joiner M.C. Particle beams in radiotherapy. In: Basic clinical radiobiology. Edited by: G.G. Steel. (Edward Arnold, London), pp. 130-141, 1993.
130. Joiner M.C. Hyperfractionation and accelerated radiotherapy. In: Basic clinical radiobiology. Edited by: G.G. Steel. (Edward Arnold, London), pp. 65-71, 1993.
131. Joiner M.C. The linear-quadratic approach to fractionation. In: Basic clinical radiobiology. Edited by: G.G. Steel. (Edward Arnold, London), pp. 55-64, 1993.
132. Joiner M.C. Models of radiation cell killing. In: Basic clinical radiobiology. Edited by: G.G. Steel. (Edward Arnold, London), pp. 40-46, 1993.
133. Lambin P., Marples B., Fertil B., Malaise E.P. and Joiner M.C. Low dose radiation response of human tumour cell lines of different intrinsic radiosensitivity. In: Prediction of Response in Radiotherapy: Radiosensitivity and Repopulation, edited by B. Paliwal, D. Herbert, J.F. Fowler and T.J. Kinsella (New York: American Institute of Physics), pp. 311-319, 1993.
134. Joiner M.C., Marples B. and Johns H. The limitation of the linear-quadratic model at low doses per fraction. In: Current topics in clinical radiobiology of tumors. Edited by H.P. Beck-Bornholdt (Berlin: Springer-Verlag), pp. 51-66, 1993.
135. Arrand J.E., Singh B., Robson T., Gamble S.C. and Joiner M.C. Molecular dissection of X-ray induced responses in human cells. In: Les Éditions de Physique, Numéro spécial de Radioprotection, 32, pp. 311-314, 1997.
136. Joiner M.C., Lambin P., Skov K.A. and Marples B. Induced radioresistance in mammalian systems. In: Les Éditions de Physique, Numéro spécial de Radioprotection, 32, pp. 397-400, 1997.
137. Joiner M.C. Models of radiation cell killing. In: Basic clinical radiobiology, Second Edition. Edited by: G.G. Steel. (Arnold, London), pp. 52-57, 1997.
138. Joiner M.C. and van der Kogel A.J. The linear-quadratic approach to fractionation and calculation of isoeffect relationships. In: Basic clinical radiobiology, Second Edition. Edited by: G.G. Steel. (Arnold, London), pp. 106-122, 1997.
139. Joiner M.C. Hyperfractionation and accelerated radiotherapy. In: Basic clinical radiobiology, Second Edition. Edited by: G.G. Steel. (Arnold, London), pp. 123-131, 1997.
140. Joiner M.C. Particle beams in radiotherapy. In: Basic clinical radiobiology, Second Edition. Edited by: G.G. Steel. (Arnold, London), pp. 173-183, 1997.
141. Joiner M.C., Short S.C., Lambin and Marples B. Homology between adaptive response and induced resistance. In: Proceedings of 11th International Congress of Radiation Research, Dublin, Ireland. Edited by Moriaty M., Mothersill C., Seymour C., Edington M., Ward J.F. and Fry R.J.M. (Allen Press for IARR), pp. 430-433, 2000.
142. Robson T., Joiner M.C., Wilson G.D., McCullough W., Price M.E., McKeown S.R. and Hirst D.G. A novel human stress-response related gene with a role in radioresistance. In: Proceedings of 11th International Congress of Radiation Research, Dublin, Ireland. Edited by Moriaty M., Mothersill C., Seymour C., Edington M., Ward J.F. and Fry R.J.M. (Allen Press for IARR), pp. 443-446, 2000.
143. Joiner M.C., Lambin P., Skov K.A. and Marples B. Radiosensitivity at low doses: low-LET radiations act like high-LET radiations. In: Status and Perspectives of Heavy Ion Therapy. Edited by Hirohiko T. (Innervision Iryokagakusha, Tokyo), pp. 58-64, 2000.
144. Baumann M., Bentzen S.M., Doerr W., Joiner M.C., Saunders M., Tannock I.F. and Thames H.D. The translational research chain: Is it delivering the goods? In: Proceedings of ICTR 2000, Lugano Switzerland. International Journal of Radiation Oncology Biology Physics, 49, 345-351, 2001.
145. Joiner M.C., Marples B., Lambin P., Short S.C. and Turesson I. Low-dose hypersensitivity: current status and possible mechanisms. In: Proceedings of ICTR 2000 Lugano Switzerland. International Journal of Radiation Oncology, Biology, Physics, 49, 379-389, 2001.
146. Joiner M.C. Models of radiation cell killing. In: Basic clinical radiobiology, Third Edition. Edited by: G.G. Steel. (Arnold, London), pp. 64-70, 2002.
147. Joiner M.C. and Bentzen S.M. Time-dose relationships: the linear-quadratic approach. In: Basic clinical radiobiology, Third Edition. Edited by: G.G. Steel. (Arnold, London), pp. 120-133, 2002.
148. Baumann M., Saunders M.I., and Joiner M.C. Modified fractionation. In: Basic clinical radiobiology, Third Edition. Edited by: G.G. Steel. (Arnold, London), pp. 147-157, 2002.
149. Joiner M.C. Particle beams in radiotherapy. In: Basic clinical radiobiology, Third Edition. Edited by: G.G. Steel. (Arnold, London), pp. 205-216, 2002.
150. Krause M., Joiner M. and Baumann M. Ultrafractionation in human malignant glioma xenografts [letter]. International Journal of Cancer, 107, 333, 2003.
151. Coleman C.N., Stone H.B., Alexander G.A., Barcellos-Hoff M.H., Bedford J.S., Bristow R.G., Dynlacht J.R., Fuks Z., Gorelic L.S., Hill R.P., Joiner M.C., Liu F.F., McBride W.H., McKenna W.G., Powell S.N., Robbins M.E.C., Rockwell S., Schiff P.B., Shaw E.G., Siemann D.W., Travis E.L., Wallner P.E., Wong R.S. and Zeman E.M. Meeting report: Education and training for radiation scientists: Radiation Research program and American Society of Therapeutic Radiology and Oncology workshop, Bethesda, Maryland, May 12-14, 2003. Radiation Research, 160, 729-737, 2003.
152. Joiner M.C. In reply to Drs. Elmehdi and Pistorius. International Journal of Radiation Oncology Biology Physics, 63, 314, 2005.
153. Pulkkanen K., Lahtinen T., Lehtimäki A., Joiner M.C. and Kataja V. Effective palliation without normal tissue toxicity using low-dose ultrafractionated re-irradiation for tumor recurrence after radical or adjuvant radiotherapy. Acta Oncologica, 46, 1037-1041, 2007.
In press
154. Joiner M.C. and Marples B. Response in vivo to high-LET radiation. In: International Atomic Energy Agency Report, Relative Biological Effectiveness and Dose Reporting in Proton and Heavier Ion Radiotherapy, 2008.
155. Marples B., Krueger S.A., Collis S.J. andJoiner M.C. Low dose hyper-radiosensitivity: a historical perspective. In: Targeted Radionuclide Tumor Therapy - Biological Aspects. Edited by Stigbrand T. and Carlsson J. (Springer, Dordrecht), 2008.